Amitriptyline

Indications & formulation #

Depression in adults; not a pain-dosing reference. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

The selected outpatient label describes 75 mg/day in divided doses, increasing if needed to 150 mg/day. Frailty and tolerability may require a lower individualized start.

Contraindications & important cautions #

Avoid MAOIs and cisapride; not recommended during acute recovery after myocardial infarction. Overdose can cause fatal conduction disturbances.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Anticholinergic effects, sedation, orthostasis and cardiac conduction toxicity; overdose can be life-threatening.

Interactions #

Review other anticholinergic, sedating, serotonergic and cardiac-conduction-affecting agents.

Monitoring #

Assess cardiac and falls risk, constipation/urinary symptoms, interactions and overdose vulnerability. Dose context differs by indication.

Special populations #

Older adults are more vulnerable to anticholinergic effects, falls and confusion; review hepatic function and cardiac disease.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

Reduce gradually; discuss safe storage and withdrawal symptoms.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.