Antidepressants
Fluoxetine
Serotonin-transporter inhibition; the active norfluoxetine metabolite contributes to prolonged persistence.
Structured reference
Medicines
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Structured references cover selected adult formulations. Brief entries provide limited context; neither is an exhaustive monograph.
Antidepressants
Sertraline
Selective serotonin-transporter inhibition, followed by downstream adaptive changes.
Structured reference
Antidepressants
Escitalopram
Selective serotonin-transporter inhibition by the S-enantiomer of citalopram.
Structured reference
Antidepressants
Citalopram
Selective serotonin-transporter inhibition.
Structured reference
Antidepressants
Paroxetine
Serotonin-transporter inhibition with clinically relevant anticholinergic and CYP2D6 effects.
Structured reference
Antidepressants
Fluvoxamine
Selective serotonin-transporter inhibition.
Structured reference
Antidepressants
Venlafaxine
Serotonin and noradrenaline reuptake inhibition; the relative contribution depends on exposure.
Structured reference
Antidepressants
Desvenlafaxine
Serotonin and noradrenaline reuptake inhibition; an active metabolite of venlafaxine.
Structured reference
Antidepressants
Duloxetine
Serotonin and noradrenaline reuptake inhibition.
Structured reference
Antidepressants
Milnacipran
Serotonin/noradrenaline reuptake inhibitor.
Brief entry
Antidepressants
Levomilnacipran
Serotonin/noradrenaline reuptake inhibitor.
Brief entry
Antidepressants
Amitriptyline
Tricyclic monoamine-reuptake inhibition with muscarinic, histamine and adrenergic effects.
Structured reference
Antidepressants
Nortriptyline
Tricyclic antidepressant with prominent noradrenaline-reuptake inhibition.
Structured reference
Antidepressants
Imipramine
Tricyclic antidepressant.
Brief entry
Antidepressants
Clomipramine
Tricyclic antidepressant with strong serotonergic reuptake effects and an active metabolite.
Structured reference
Antidepressants
Desipramine
Tricyclic antidepressant.
Brief entry
Antidepressants
Doxepin
Tricyclic antidepressant; formulations span different indications.
Brief entry
Antidepressants
Trimipramine
Tricyclic antidepressant.
Brief entry
Antidepressants
Dosulepin
Tricyclic antidepressant.
Brief entry
Antidepressants
Bupropion
Noradrenaline and dopamine reuptake effects; it is not an SSRI.
Structured reference
Antidepressants
Mirtazapine
Presynaptic alpha-2 antagonism and serotonin-receptor effects; H1 antagonism contributes to sedation.
Structured reference
Antidepressants
Mianserin
Tetracyclic; alpha-adrenoceptor and antihistamine actions.
Brief entry
Antidepressants
Trazodone
Serotonin-reuptake inhibition and receptor antagonism; effects vary with exposure.
Structured reference
Antidepressants
Vortioxetine
Serotonin-transporter inhibition combined with several serotonin-receptor actions.
Structured reference
Antidepressants
Vilazodone
Serotonin reuptake inhibition and 5-HT1A partial agonism.
Brief entry
Antidepressants
Agomelatine
MT1/MT2 agonism and 5-HT2C antagonism.
Brief entry
Antidepressants
Tianeptine
Mechanism and locally authorized psychiatric product information require source verification.
Brief entry
Antidepressants
Phenelzine
Monoamine oxidase inhibitor.
Brief entry
Antidepressants
Tranylcypromine
Irreversible monoamine oxidase inhibition.
Brief entry
Antidepressants
Moclobemide
Reversible monoamine oxidase-A inhibitor.
Brief entry
Antidepressants
Selegiline
Monoamine oxidase inhibition; selectivity depends on exposure.
Brief entry
Antidepressants
Dextromethorphan/bupropion
NMDA/sigma-1 activity from dextromethorphan; bupropion inhibits CYP2D6 and raises its exposure.
Brief entry
Antidepressants
Esketamine
S-enantiomer of ketamine; NMDA receptor antagonism.
Brief entry
Antidepressants
Brexanolone
Neuroactive steroid; full product source remains to verify.
Brief entry
Antidepressants
Zuranolone
Positive allosteric modulation of GABA-A receptors.
Brief entry
Antipsychotics
Chlorpromazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Haloperidol
Potent dopamine D2 receptor antagonism.
Structured reference
Antipsychotics
Fluphenazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Trifluoperazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Perphenazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Thioridazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Pimozide
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Zuclopenthixol
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Flupentixol
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Loxapine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Clozapine
Broad receptor effects with a clinical role in appropriately assessed treatment resistance.
Structured reference
Antipsychotics
Risperidone
Dopamine D2 and serotonin 5-HT2 receptor antagonism.
Structured reference
Antipsychotics
Paliperidone
Dopamine D2/serotonin 5-HT2 antagonism; active risperidone metabolite.
Structured reference
Antipsychotics
Olanzapine
Dopamine and serotonin receptor antagonism with additional histamine, muscarinic and adrenergic effects.
Structured reference
Antipsychotics
Quetiapine
Dopamine/serotonin receptor effects; the active metabolite has additional pharmacological actions.
Structured reference
Antipsychotics
Aripiprazole
Partial dopamine D2/D3 and serotonin 5-HT1A agonism with 5-HT2A antagonism.
Structured reference
Antipsychotics
Brexpiprazole
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Cariprazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Ziprasidone
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Lurasidone
Dopamine D2 and serotonin receptor antagonism.
Structured reference
Antipsychotics
Amisulpride
Selective dopamine D2/D3 antagonism.
Structured reference
Antipsychotics
Sulpiride
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Asenapine
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Iloperidone
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Lumateperone
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Sertindole
Generic medicine reference. Open the entry for the information available.
Brief entry
Antipsychotics
Xanomeline/trospium
Generic medicine reference. Open the entry for the information available.
Brief entry
Mood stabilizers
Lithium
Multiple intracellular signaling effects; clinical action is not explained by a single receptor.
Structured reference
Mood stabilizers
Valproate family
Multiple effects on inhibitory signaling and ion channels.
Structured reference
Mood stabilizers
Carbamazepine
Voltage-sensitive sodium-channel blockade with substantial metabolic enzyme induction.
Structured reference
Mood stabilizers
Lamotrigine
Voltage-sensitive sodium-channel effects with reduced excitatory neurotransmission.
Structured reference
Mood stabilizers
Oxcarbazepine
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Alprazolam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Clonazepam
Benzodiazepine enhancement of GABA-A signaling.
Structured reference
Anxiety and sleep
Diazepam
Positive allosteric modulation of GABA-A receptors; active metabolites contribute to prolonged effects.
Structured reference
Anxiety and sleep
Lorazepam
Positive allosteric modulation of GABA-A receptors.
Structured reference
Anxiety and sleep
Oxazepam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Temazepam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Chlordiazepoxide
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Clobazam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Midazolam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Nitrazepam
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Zolpidem
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Zopiclone
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Eszopiclone
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Zaleplon
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Buspirone
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Hydroxyzine
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Melatonin
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Ramelteon
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Suvorexant
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Lemborexant
Generic medicine reference. Open the entry for the information available.
Brief entry
Anxiety and sleep
Daridorexant
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Methylphenidate
Inhibition of dopamine and noradrenaline reuptake.
Structured reference
ADHD
Dexmethylphenidate
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Dexamfetamine
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Mixed amfetamine salts
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Lisdexamfetamine
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Atomoxetine
Selective noradrenaline-transporter inhibition.
Structured reference
ADHD
Guanfacine
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Clonidine
Generic medicine reference. Open the entry for the information available.
Brief entry
ADHD
Viloxazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Substance use
Naltrexone
Opioid receptor antagonism.
Structured reference
Substance use
Acamprosate
Modulates neurotransmission associated with alcohol dependence; mechanism is not fully established.
Structured reference
Substance use
Disulfiram
Inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation with alcohol.
Structured reference
Substance use
Buprenorphine
Partial mu-opioid receptor agonism.
Structured reference
Substance use
Buprenorphine/naloxone
Buprenorphine partial agonism with naloxone to discourage parenteral misuse.
Structured reference
Substance use
Methadone
Full mu-opioid receptor agonism with prolonged, variable elimination.
Structured reference
Substance use
Lofexidine
Generic medicine reference. Open the entry for the information available.
Brief entry
Substance use
Nicotine
Nicotine receptor agonism reduces tobacco withdrawal.
Structured reference
Substance use
Varenicline
Partial agonism at alpha4beta2 nicotinic receptors.
Structured reference
Substance use
Cytisine
Generic medicine reference. Open the entry for the information available.
Brief entry
Substance use
Naloxone
Competitive opioid receptor antagonism.
Structured reference
Substance use
Nalmefene
Generic medicine reference. Open the entry for the information available.
Brief entry
Dementia
Donepezil
Acetylcholinesterase inhibition; it is symptomatic treatment rather than a cure for neurodegeneration.
Structured reference
Dementia
Rivastigmine
Generic medicine reference. Open the entry for the information available.
Brief entry
Dementia
Galantamine
Generic medicine reference. Open the entry for the information available.
Brief entry
Dementia
Memantine
Uncompetitive NMDA receptor antagonism.
Structured reference
Dementia
Lecanemab
Generic medicine reference. Open the entry for the information available.
Brief entry
Dementia
Donanemab
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Propranolol
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Trihexyphenidyl
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Benztropine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Biperiden
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Amantadine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Valbenazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Deutetrabenazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Tetrabenazine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Gabapentin
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Pregabalin
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Topiramate
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Ketamine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Modafinil
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Armodafinil
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Liothyronine
Generic medicine reference. Open the entry for the information available.
Brief entry
Adjuncts
Promethazine
Generic medicine reference. Open the entry for the information available.
Brief entry