Bupropion

Indications & formulation #

Major depressive disorder in adults; not a smoking-cessation formulation guide. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral XL extended-release tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Start XL 150 mg each morning; after four days, the label permits increasing to the 300 mg/day target. Swallow whole; avoid duplicate bupropion products.

Contraindications & important cautions #

Contraindications include seizure disorder, current/prior anorexia or bulimia, MAOIs and abrupt withdrawal of alcohol or sedatives/antiepileptics.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Insomnia, activation and dose-related seizure concerns are clinically important; product contraindications must be checked.

Interactions #

CYP2D6 inhibition can affect other medicines. Release formulations and combination products have distinct instructions.

Monitoring #

Review seizure/eating-disorder history, blood pressure, sleep, activation and the exact depression or smoking-cessation product.

Special populations #

Moderate/severe hepatic impairment: maximum 150 mg alternate days. Renal impairment may require reduced dose/frequency.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

The XL label reduces 300 mg/day to 150 mg/day before discontinuation; reassess mood and activation.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.