Indications & formulation #
Anxiety in adults; not an injectable sedation protocol. This reference covers the selected formulation; other indications and products need their own evidence.
Dose reference #
Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.
Selected initial anxiety dose: 2–3 mg/day in two or three doses; usual range 2–6 mg/day. Individualize to response and sedation.
Contraindications & important cautions #
Avoid acute narrow-angle glaucoma and hypersensitivity. Opioids/alcohol increase respiratory depression; assess dependence risk.
Selected important cautions; consult the full product information for all contraindications and warnings.
Adverse effects #
Sedation, amnesia, motor impairment, dependence and withdrawal; respiratory risk rises with other depressants.
Interactions #
Assess opioids, alcohol and other sedatives. Different routes have different administration/monitoring requirements.
Monitoring #
Review indication, duration, response, sedation and respiratory context. Abrupt withdrawal after dependence can be dangerous.
Special populations #
Older/debilitated patients: initial 1–2 mg/day divided. Review respiratory disease, hepatic illness and pregnancy/neonatal effects.
Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.
Discontinuation, restarting & counseling #
Use a gradual individualized taper; abrupt cessation may cause seizures or delirium.
Condition-specific prescribing #
Additional indication-specific records retain their own formulation and source context.
Lorazepam
Rapid tranquillisation in a monitored adult setting
Adults; not a frail-older-adult or paediatric schedule · Intramuscular injection; prepare according to the selected product · Intramuscular · UK local NHS rapid-tranquillisation protocol; not a universal maximum or Indian approval claim.
- Starting dose
- 0.5–2 mg as a single dose in the cited Midlands NHS protocol.
- Titration
- Reassess before any repeat; the cited minimum interval is 1–2 hours.
- Treatment range / target
- 0.5–2 mg per administration.
- Maximum / limits
- 4 mg in 24 hours in this local protocol; count all lorazepam routes. Higher dosing requires a separately authorized senior plan.
- Trial & duration
- Acute episode only, with review before repeat administration.
- Monitoring
- Respiration, oxygen saturation, blood pressure, pulse, temperature and consciousness; resuscitation capability available.
- Population & organ-function adjustments
- Select a lower dose or different plan for frailty, organ impairment or concurrent sedatives; this adult schedule must not be extrapolated automatically.
- Important cautions
- Avoid in respiratory depression; alcohol/opioids and other sedatives increase respiratory risk. Distinguish withdrawal from intoxication. Do not mix medicines in the syringe without product compatibility instructions.
Brands & products #
Historical catalogue observations. Prices and catalogue presence do not establish current availability or Indian approval.
Reference coverage #
Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.
References · 4
- Lorazepam — Oral tablet — selected prescribing information · United States · Checked 2026-10-27 · Selected formulation: Oral tablet · Supports indications, dose, cautions, adverse effects, interactions, monitoring, special populations and stopping. Source sections: Indications and usage; Dosage and administration; Contraindications; warnings and precautions; Use in specific populations; patient counseling
- Midlands Partnership: rapid tranquillisation formulary · United Kingdom; local NHS protocol · Checked 2026-10-26 · Supports: Lorazepam — Rapid tranquillisation in a monitored adult setting (Intramuscular injection; prepare according to the selected product)
- NICE NG10: violence and aggression · United Kingdom · Checked 2026-10-26 · Supports: Lorazepam — Rapid tranquillisation in a monitored adult setting (Intramuscular injection; prepare according to the selected product)
- RDaSH: rapid tranquillisation policy · United Kingdom; local NHS protocol · Checked 2026-10-26 · Supports: Lorazepam — Rapid tranquillisation in a monitored adult setting (Intramuscular injection; prepare according to the selected product)